Asymmetric Catalysis


Asymmetric catalysis is the use of a chiral catalyst that favors the formation of one stereoisomer. A chiral feature biases the formation of one stereoisomer through interactions at the transition state. Identification of chiral catalyst and reaction conditions often requires empircal optimization. C-CAS seeks to integrate data chemistry to inform the selection of optimal catalysts and bypass time-consuming traditional reaction development strategies.


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  • Hardy, M.A.; Cooke, J.H.; Feng, Z.; Noda, K.; Kerschgens, I.; Massey, L.A.; Tantillo, D.J.; Sarpong, R. Unified Synthesis of 2-Isocyanoallopupukeanane and 9-Isocyanopupukeanane through a "Contra-biosynthetic" Rearrangement. Angew. Chem. Int. Ed. 2024, 63.